ea0041gp158 | Pituitary - Clinical | ECE2016
Thieroff-Ekerdt Ruth
, Mould Diane
Ketoconazole is a 50/50 racemic mixture of two enantiomers (2S,4R and 2R,4S) used off label in the US for the treatment of endogenous Cushings syndrome by virtue of adrenal cortisol synthesis inhibition.COR-003 (levoketoconazole) is the more potent single (2S,4R) enantiomer of ketoconazole (KTZ) to inhibit adrenal cortisol synthesis and is currently being investigated in a multinational Phase 3 study for the treatment of endogenous Cushings s...